Telomere maintenance in childhood primitive neuroectodermal brain tumors
نویسندگان
چکیده
منابع مشابه
Current outcome predictors in childhood primitive neuroectodermal tumors
Central nervous system primitive neuroectodermal tumors (PNET) including cerebellar PNET (medulloblastoma, PNET/ MB) are the most common malignant brain tumors in childhood. Because of the high risk of leptomeningeal dissemination, standard postoperative treatment for PNET includes craniospinal radiotherapy and chemotherapy. Such treatment causes long-term morbidity including endocrine and grow...
متن کاملChemotherapy for Childhood Medulloblastoma and Primitive Neuroectodermal Tumors.
Medulloblastoma is the most common form of childhood brain tumor, and management has evolved over the past two decades. Chemotherapy is now an integral part of the treatment of the majority, if not all, patients with this disease. Medulloblastoma is a chemosensitive tumor, and recurrent disease will often respond to a variety of different chemotherapeutic agents. The use of higher-dose chemothe...
متن کاملPediatric Orbital Primitive Neuroectodermal Tumors.
PURPOSE To present the clinical, radiological, histopathological, immunohistochemical features and the follow-up of orbital primitive neuroectodermal tumors (PNETs) in pediatric patients along with a review of the literature. METHODS A retrospective analysis of all diagnosed cases of orbital PNET was done. Patients' ophthalmic findings, imaging, immunohistochemistry, metastatic work-up, treat...
متن کاملSupratentorial primitive neuroectodermal tumors in young children.
TO THE EDITOR: In the April issue of the Journal of Clinical Oncology, Timmermann et al suggest that radiotherapy plays a major role in the treatment of young children with supratentorial primitive neuroectodermal tumors (stPNET) and conclude that a delay in irradiation may compromise survival. Although stPNET are undoubtedly aggressive brain tumors and results of treatments are still disappoin...
متن کاملComputed tomography of primitive neuroectodermal tumors.
The primitive neuroectodermal tumor is a neoplasm of young individuals that occurs predominantly in the supratentorial compartment. It appears on computed tomography as a bulky mass, often with calcification with predominantly homogeneous enhancement but on occasion with cystic or necrotic areas. Cerebrospinal fluid seeding was observed in more than half the cases in our series. The patients ha...
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ژورنال
عنوان ژورنال: Neuro-Oncology
سال: 2004
ISSN: 1523-5866,1522-8517
DOI: 10.1215/s1152851703000176